Due to the recognition that whole-body cryotherapy is proving to be effective for autoimmune conditions, recently clinical trials are being conducted to explore this area in more depth. In 2018 and randomised clinical trial was conducted to explore the effects of cryotherapy in those with fibromyalgia, an autoimmune disease resulting in significant muscle and joint pain. This study concluded that after 1 month of cryotherapy the patients reported significant reductions in pain and an improved quality of life both physically and mentally